Speaker

Yang Shi, Harvard University, USA
Yang Shi

My laboratory has a longstanding interest in understanding the molecular mechanisms that regulate mammalian transcription and chromatin. We identified the first histone demethylase LSD1 in 2004 and numerous JmjC-type demethylases in 2006, demonstrating the dynamic nature of histone methylation regulation, a modification that was long considered irreversible. We continue to investigate the mechanisms that underlie dynamic regulation of histone methylation, as well as proteins that recognize various methylated and unmethylated states of histones, and the impact on both physiological and pathological conditions.

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