Dirk Schübeler obtained his PhD from the University of Braunschweig, Germany for work on cis-regulatory sequences that bind to the nuclear matrix. His postdoctoral studies with Mark Groudine in Seattle, USA focused on epigenetic phenomena involved in mammalian gene regulation.
In 2003 he established his own group at the Friedrich Miescher Institute in Basel continuing to study the regulation of chromatin and DNA methylation at the level of the genome. This has lead to comprehensive views on the genomic pattern of histone modifications, replication timing and DNA methylation during cellular differentiation and the regulation of these processes. Recent work also employs genome editing approaches to determine how DNA sequence influences the local chromatin state.
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