The Amit lab aims at understanding how mammals encode complex regulatory functions in their genomes with focus on hematopoiesis and immune responses. For this we combine development of novel single cell genomic methods and models for gene regulation and epigenetic research coupled to computational techniques, modern high throughput sequencing technologies and targeted experiments. Our mission is to uncover fundamental principles of genome function and regulation and how they impact blood development and immune homeostasis in both health and disease. Recently, my group has made conceptual progress in understanding epigenetic control of the Immune system and the coding of immunity in the genome. These discoveries are expected to make substantial impact on both basic science and future medicine. In line, our discoveries greatly impacts future research directions in the genomic and immunity communities alike. Several of our research breakthrough include: (i) Understanding mechanisms of transcriptional and chromatin regulation in hematopoiesis and immune response (Rabani et al, Nature Biotechnology 2011; Garber et al, Molecular Cell 2012; Gat Vicks et al, Nature Biotechnology 2013; Lara et al, Science 2014; Jaitin et al, Science 2014b; Bornstein et al’ Molecular Cell 2014; Lavin et al, Cell 2014 and (ii) understanding gene circuits and the cellular complexity controlling immune response (Chevrier et al, Cell 2011, Altbaum et al, Molecular Systems Biology 2014; Baruch et al, Science 2014; Cohen et al, EMBO 2014). Additional efforts were devoted to develop novel next generation sequencing approaches for in vivo analysis of chromatin and single cell gene expression dynamics (Cheng et al Nature Communications 2013; Blecher et al, Nature Protocols 2013; Jaitin et al, Science 2014, Lara et al, Science 2014, and work in progress).
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